Integrative Microbiome Sciences Laboratory

The resolution of current studies investigating bacterial pathogenesis and the microbiome describes a defined consortium of commensal microbes that can, for example, reduce the magnitude of pathogen colonisation; however, understanding the network of metabolic shifts relative to the gut microbiota remains challenging.
Our lab develops strategies for engineering the metabolic potential of the gut microbiome for treating and modulating host health outcomes following infection with multi-drug resistant bacteria.
We combine molecular microbiology, microbiome sciences, bioinformatics, and multi-omic approaches towards defining causal mechanisms in microbial communities (e.g., metabolic hand-off processes) in an effort to then rationally reprogram those communities toward desired health phenotypes.
Our lab is particularly focused on infectious disease biology and antimicrobial resistance, where the ability to map, measure, and perturb microbial functions in situ has translational implications.